Macro histone H2A1.2 (MacroH2A1) protein suppresses mitotic kinase VRK1 during interphase

• Main Authors: Kim, Wanil, Chakraborty, Goutam, Kim, Sangjune, Shin, Joon, Park, Choon-Ho, Jeong, Min-Woo, Bharatham, Nagakumar, Yoon, Ho Sup, Kim, Kyong-Tai
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/104401; http://hdl.handle.net/10220/17067
• Institution: Nanyang Technological University

VRK1-mediated phosphorylation of histone H3 should be restricted in mitosis for consistent cell cycling, and defects in this process trigger cellular catastrophe. However, an interphasic regulator against VRK1 has not been actually investigated so far. Here, we show that the histone variant macrodom...