Modulating drug release from poly(lactic-co-glycolic acid) thin films through terminal end-groups and molecular weight

• Main Authors: Boey, Freddy Yin Chiang, Huang, Charlotte L., Kumar, Saranya, Tan, John J. Z., Venkatraman, Subbu S., Steele, Terry W. J., Loo, Joachim Say Chye
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/104528; http://hdl.handle.net/10220/20228
• Institution: Nanyang Technological University

Biodegradable PLGA is commonly employed for controlled drug release on the order of weeks to months. Hydrophobic drugs distribute homogeneously in PLGA, but their strong hydrophobic interaction typically results in narrow release profiles. In this study, three molecular weights (MW) and two diffe...