Modulating drug release from poly(lactic-co-glycolic acid) thin films through terminal end-groups and molecular weight

• المؤلفون الرئيسيون: Boey, Freddy Yin Chiang, Huang, Charlotte L., Kumar, Saranya, Tan, John J. Z., Venkatraman, Subbu S., Steele, Terry W. J., Loo, Joachim Say Chye
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Engineering::Materials
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/104528; http://hdl.handle.net/10220/20228
• المؤسسة: Nanyang Technological University

Biodegradable PLGA is commonly employed for controlled drug release on the order of weeks to months. Hydrophobic drugs distribute homogeneously in PLGA, but their strong hydrophobic interaction typically results in narrow release profiles. In this study, three molecular weights (MW) and two diffe...