ZnO nanowire array-templated LbL self-assembled polyelectrolyte nanotube arrays and application for charged drug delivery

Vertically oriented and robust polyelectrolyte nanotube arrays with high density, large area and high uniformity were successfully grown on substrates by a ZnO nanowire array-templated layer-by-layer (LbL) self-assembly approach for the first time, and were further used to deliver charged drugs, sho...

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Bibliographic Details
Main Authors: Yuan, Weiyong, Lu, Zhisong, Liu, Jinping, Wang, Huili, Li, Chang Ming
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/104610
http://hdl.handle.net/10220/16562
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Institution: Nanyang Technological University
Language: English
Description
Summary:Vertically oriented and robust polyelectrolyte nanotube arrays with high density, large area and high uniformity were successfully grown on substrates by a ZnO nanowire array-templated layer-by-layer (LbL) self-assembly approach for the first time, and were further used to deliver charged drugs, showing that they not only possess pH-responsive loading property, but also significantly enhance the loading capacity and sustained release time. This work could be extended to fabricate polyelectrolyte nanotube arrays with different polyelectrolyte combinations, including weak polyelectrolyte/weak polyelectrolyte, weak polyelectrolyte/strong polyelectrolyte and strong polyelectrolyte/strong polyelectrolyte. With the great versatility to use various substrates and building blocks, the polyelectrolyte nanotube arrays may have great potential for broad applications such as biosensor arrays, bioreactor arrays and optoelectronics.