Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectr...

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Bibliographic Details
Main Authors: Cui, Dongyao, Liu, Xinyu, Zhang, Jing, Yu, Xiaojun, Ding, Sun, Luo, Yuemei, Gu, Jun, Shum, Ping, Liu, Linbo
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics
Online Access:https://hdl.handle.net/10356/104749
http://hdl.handle.net/10220/24665
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Institution: Nanyang Technological University
Language: English
Description
Summary:1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details.

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