Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo

1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectr...

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Main Authors: Cui, Dongyao, Liu, Xinyu, Zhang, Jing, Yu, Xiaojun, Ding, Sun, Luo, Yuemei, Gu, Jun, Shum, Ping, Liu, Linbo
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2015
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Online Access:https://hdl.handle.net/10356/104749
http://hdl.handle.net/10220/24665
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1047492020-03-07T11:40:19Z Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo Cui, Dongyao Liu, Xinyu Zhang, Jing Yu, Xiaojun Ding, Sun Luo, Yuemei Gu, Jun Shum, Ping Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics 1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details. NMRC (Natl Medical Research Council, S’pore) Accepted version 2015-01-19T08:30:39Z 2019-12-06T21:38:51Z 2015-01-19T08:30:39Z 2019-12-06T21:38:51Z 2014 2014 Journal Article Cui, D., Liu, X., Zhang, J., Yu, X., Ding, S., Luo, Y., et al. (2014). Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo. Optics letters, 39(23), 6727-6730. https://hdl.handle.net/10356/104749 http://hdl.handle.net/10220/24665 10.1364/OL.39.006727 en Optics letters © 2014 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Optics Letters, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [Article DOI: http://dx.doi.org/10.1364/OL.39.006727]. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics
spellingShingle DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics
Cui, Dongyao
Liu, Xinyu
Zhang, Jing
Yu, Xiaojun
Ding, Sun
Luo, Yuemei
Gu, Jun
Shum, Ping
Liu, Linbo
Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
description 1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Cui, Dongyao
Liu, Xinyu
Zhang, Jing
Yu, Xiaojun
Ding, Sun
Luo, Yuemei
Gu, Jun
Shum, Ping
Liu, Linbo
format Article
author Cui, Dongyao
Liu, Xinyu
Zhang, Jing
Yu, Xiaojun
Ding, Sun
Luo, Yuemei
Gu, Jun
Shum, Ping
Liu, Linbo
author_sort Cui, Dongyao
title Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
title_short Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
title_full Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
title_fullStr Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
title_full_unstemmed Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
title_sort dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
publishDate 2015
url https://hdl.handle.net/10356/104749
http://hdl.handle.net/10220/24665
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