Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Objectives:Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We...

Full description

Saved in:
Bibliographic Details
Main Authors: Jakobsen, Tim H., Christensen, Louise Dahl, Gennip, Maria van, Alhede, Morten, Hougen, Hans Petter, Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences::Microbiology
Online Access:https://hdl.handle.net/10356/104841
http://hdl.handle.net/10220/17023
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/104841
http://hdl.handle.net/10220/17023

Similar Items