Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

• Main Authors: Jakobsen, Tim H., Christensen, Louise Dahl, Gennip, Maria van, Alhede, Morten, Hougen, Hans Petter, Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/104841; http://hdl.handle.net/10220/17023
• Institution: Nanyang Technological University

Objectives:Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We...