Feasibility of the assessment of cholesterol crystals in human macrophages using micro optical coherence tomography

• Main Authors: Tanaka, Atsushi, Kashiwagi, Manabu, Liu, Linbo, Chu, Kengyeh K., Sun, Chen-Hsin, Gardecki, Joseph A., Tearney, Guillermo J.
• Other Authors: van Zandvoort, Marc
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104865; http://hdl.handle.net/10220/20285
• Institution: Nanyang Technological University

The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque p...