Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2

• Main Authors: Chee, Sharon Min Qi, Wongsantichon, Jantana, Soo Tng, Quah, Robinson, Robert, Joseph, Thomas L., Verma, Chandra, Lane, David P., Brown, Christopher J., Ghadessy, Farid J.
• Other Authors: Maki, Carl G.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105057; http://hdl.handle.net/10220/20419
• Institution: Nanyang Technological University

As key negative regulator of the p53 tumour suppressor, Mdm2 is an attractive therapeutic target. Small molecules such as Nutlin have been developed to antagonise Mdm2, resulting in p53-dependent death of tumour cells. We have recently described a mutation in Mdm2 (M62A), which precludes binding of...