Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

• Main Authors: Maji, Swarup Kumar, Sreejith, Sivaramapanicker, Joseph, James, Lin, Manjing, He, Tingchao, Tong, Yan, Sun, Handong, Yu, Sidney Wing-Kwong, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/105138; http://hdl.handle.net/10220/20503; http://dx.doi.org/10.1002/adma.201400831
• Institution: Nanyang Technological University

An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covere...