Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covere...

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Bibliographic Details
Main Authors: Maji, Swarup Kumar, Sreejith, Sivaramapanicker, Joseph, James, Lin, Manjing, He, Tingchao, Tong, Yan, Sun, Handong, Yu, Sidney Wing-Kwong, Zhao, Yanli
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Engineering::Materials
Online Access:https://hdl.handle.net/10356/105138
http://hdl.handle.net/10220/20503
http://dx.doi.org/10.1002/adma.201400831
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Institution: Nanyang Technological University
Language: English
Description
Summary:An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

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