Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity

• Main Authors: Purnama, Christina, Ng, See Liang, Tetlak, Piotr, Setiagani, Yolanda Aphrilia, Kandasamy, Matheswaran, Baalasubramanian, Sivasankar, Karjalainen, Klaus, Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/105157; http://hdl.handle.net/10220/20697; http://dx.doi.org/10.1002/eji.201344359
• Institution: Nanyang Technological University

Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo abla...