Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity
Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo abla...
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| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/105157 http://hdl.handle.net/10220/20697 http://dx.doi.org/10.1002/eji.201344359 |
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| Institution: | Nanyang Technological University |
| Language: | English |