ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis

• Main Authors: Lam, TYW, Nguyen, N, Peh, HY, Shanmugasundaram, M, Chandna, R, Tee, JH, Ong, CB, Hossain, MZ, Venugopal, S, Zhang, T, Xu, S, Qiu, T, Kong, WT, Chakarov, S, Srivastava, S, Liao, W, Kim, JS, Ming Teh, Ginhoux, F, Wong, WSF, Ge, R
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: Proceedings of the National Academy of Sciences 2022
• Subjects: ISM1; alveolar macrophages; apoptosis; cell surface GRP78; chronic obstructive pulmonary disease; Alveolar Epithelial Cells; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Female; Homeostasis; Inflammation; Intercellular Signaling Peptides and Proteins; Lung; Macrophages, Alveolar; Male; Mice; Mice, Inbred BALB C; Phagocytosis; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Smoke; Smoking; Tobacco
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/229045
• Institution: National University of Singapore

10.1073/pnas.2019161119