The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

• المؤلفون الرئيسيون: Soncin, Irene, Sheng, Jianpeng, Chen, Qi, Foo, Shihui, Duan, Kaibo, Lum, Josephine, Poidinger, Michael, Zolezzi, Francesca, Karjalainen, Klaus, Ruedl, Christiane
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89512; http://hdl.handle.net/10220/44929; https://doi.org/10.21979/N9/EQXCRF

Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decli...