Two combinatorial optimization problems for SNP discovery using base-specific cleavage and mass spectrometry

• Main Authors: Chen, Xin, Wu, Qiong, Sun, Ruimin, Zhang, Louxin
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biomathematics
• Online Access: https://hdl.handle.net/10356/105219; http://hdl.handle.net/10220/16762
• Institution: Nanyang Technological University

The discovery of single-nucleotide polymorphisms (SNPs) has important implications in a variety of genetic studies on human diseases and biological functions. One valuable approach proposed for SNP discovery is based on base-specific cleavage and mass spectrometry. However, it is still very challeng...