The small hydrophobic protein of the human respiratory syncytial virus forms pentameric ion channels

• Main Authors: Gan, Siok-Wan, Tan, Edward, Lin, Xin, Yu, Dejie, Wang, Juejin, Tan, Gregory Ming-Yeong, Vararattanavech, Ardcharaporn, Yeo, Chiew Ying, Soon, Cin Huang, Soong, Tuck Wah, Pervushin, Konstantin, Torres, Jaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/105290; http://hdl.handle.net/10220/17083
• Institution: Nanyang Technological University

The small hydrophobic (SH) protein is encoded by the human respiratory syncytial virus. Its absence leads to viral attenuation in the context of whole organisms, and it prevents apoptosis in infected cells. Herein, we have examined the structure of SH protein in detergent micelles and in lipid bilay...