Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure

• Main Authors: Fang, Fang, Xu, Yifeng, Chew, Kai-Khen, Chen, Xi, Ng, Huck-Hui, Matsudaira, Paul
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105306; http://hdl.handle.net/10220/20487; http://dx.doi.org/10.1002/stem.1705
• Institution: Nanyang Technological University

Master transcription factors Oct4, Sox2, and Nanog are required to maintain the pluripotency and self-renewal of embryonic stem cells (ESCs) by regulating a specific transcriptional network. A few other transcription factors have been shown to be important in ESCs by interacting with these master tr...