Electrospun poly(L-Lactic Acid) nanofibres loaded with Dexamethasone to induce osteogenic differentiation of human mesenchymal stem cells

• Main Authors: Nguyen, Luong T. H., Liao, Susan, Chan, Casey K., Ramakrishna, Seeram
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/105321; http://hdl.handle.net/10220/17685; http://www.tandfonline.com/doi/abs/10.1163/092050611X597807#.UnDNG3B0z5w
• Institution: Nanyang Technological University

Dexamethasone (Dex), a synthetic corticosteroid, was loaded into poly(L-lactic acid) (PLLA) nanofibrous scaffolds with a concentration of 0.333 wt% by electrospinning. The Dex-loaded PLLA nanofibres increased the mechanical strength in comparison with pure PLLA nanofibres. A sustained release prof...