Super-enhancer-driven long non-coding RNA LINC01503, regulated by TP63, is over-expressed and oncogenic in squamous cell carcinoma

• Main Authors: Xie, Jian-Jun, Jiang, Yan-Yi, Jiang, Yuan, Li, Chun-Quan, Lim, Mei-Chee, An, Omer, Mayakonda, Anand, Ding, Ling-Wen, Long, Lin, Sun, Chun, Lin, Le-Hang, Chen, Li, Wu, Jian-Yi, Wu, Zhi-Yong, Cao, Qi, Fang, Wang-Kai, Yang, Wei, Soukiasian, Harmik, Meltzer, Stephen J., Yang, Henry, Fullwood, Melissa, Xu, Li-Yan, Li, En-Min, Lin, De-Chen, Koeffler, H. Phillip
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Oncongenesis; Gene Regulation; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105429; http://hdl.handle.net/10220/48670
• Institution: Nanyang Technological University

Background & Aims: Long non-coding RNAs (lncRNAs) are expressed in tissue-specific pattern, but it is not clear how these are regulated. We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression and function. Methods: We studied...