Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment

• Main Authors: Li, Yan, Lim, Sierin, Ooi, Chui Ping
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
• Online Access: https://hdl.handle.net/10356/105525; http://hdl.handle.net/10220/17650; http://dx.doi.org/10.1007/s11095-011-0600-9
• Institution: Nanyang Technological University

Purpose To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP). Methods CDDP was loaded onto Fe5 (Fe3+ doped hydroxyapatite at atomic ratio of Feadded/Caadded = 5%) nanoparticles through surface adsorption. Subsequently, CDDP-loaded Fe5 nanoparticles (CDDP...