Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment
Purpose To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP). Methods CDDP was loaded onto Fe5 (Fe3+ doped hydroxyapatite at atomic ratio of Feadded/Caadded = 5%) nanoparticles through surface adsorption. Subsequently, CDDP-loaded Fe5 nanoparticles (CDDP...
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sg-ntu-dr.10356-1055252019-12-06T21:52:58Z Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment Li, Yan Lim, Sierin Ooi, Chui Ping School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology Purpose To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP). Methods CDDP was loaded onto Fe5 (Fe3+ doped hydroxyapatite at atomic ratio of Feadded/Caadded = 5%) nanoparticles through surface adsorption. Subsequently, CDDP-loaded Fe5 nanoparticles (CDDP-Fe5) and/or CDDP were encapsulated into poly(lactide-co-glycolide) (PLGA) microspheres using oil-in-water single emulsion. Drug release profiles and degradation behaviors were monitored. Results CDDP-Fe5 demonstrated a high initial burst (42% on day 1) and short release time (25 days) as CDDP was directly released from Fe5 nanoparticles. CDDP-Fe5 encapsulated within the PLGA microspheres revealed a lower initial burst (23% on day 1) and longer release time (55 days) than CDDP-Fe5. Compared with PLGA microspheres containing only CDDP, which showed typical biphasic release manner, microspheres with CDDP-Fe5 and CDDP demonstrated a nearly linear release after the initial burst. Fe5 and CDDP delayed microsphere degradation. All samples became porous, disintegrated, fused, and formed pellets at the end of the study. Conclusion Fe5/PLGA composite microspheres showed favorable CDDP release behavior compared to microspheres composed of polymer alone, suggesting its potential as a new CDDP formulation. 2013-11-15T02:29:49Z 2019-12-06T21:52:58Z 2013-11-15T02:29:49Z 2019-12-06T21:52:58Z 2011 2011 Journal Article Li, Y., Lim, S., & Ooi, C. P. (2011). Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment. Pharmaceutical research, 29(3), 756-769. 0724-8741 https://hdl.handle.net/10356/105525 http://hdl.handle.net/10220/17650 http://dx.doi.org/10.1007/s11095-011-0600-9 en Pharmaceutical research |
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DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology Li, Yan Lim, Sierin Ooi, Chui Ping Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
description |
Purpose
To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP).
Methods
CDDP was loaded onto Fe5 (Fe3+ doped hydroxyapatite at atomic ratio of Feadded/Caadded = 5%) nanoparticles through surface adsorption. Subsequently, CDDP-loaded Fe5 nanoparticles (CDDP-Fe5) and/or CDDP were encapsulated into poly(lactide-co-glycolide) (PLGA) microspheres using oil-in-water single emulsion. Drug release profiles and degradation behaviors were monitored.
Results
CDDP-Fe5 demonstrated a high initial burst (42% on day 1) and short release time (25 days) as CDDP was directly released from Fe5 nanoparticles. CDDP-Fe5 encapsulated within the PLGA microspheres revealed a lower initial burst (23% on day 1) and longer release time (55 days) than CDDP-Fe5. Compared with PLGA microspheres containing only CDDP, which showed typical biphasic release manner, microspheres with CDDP-Fe5 and CDDP demonstrated a nearly linear release after the initial burst. Fe5 and CDDP delayed microsphere degradation. All samples became porous, disintegrated, fused, and formed pellets at the end of the study.
Conclusion
Fe5/PLGA composite microspheres showed favorable CDDP release behavior compared to microspheres composed of polymer alone, suggesting its potential as a new CDDP formulation. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Li, Yan Lim, Sierin Ooi, Chui Ping |
format |
Article |
author |
Li, Yan Lim, Sierin Ooi, Chui Ping |
author_sort |
Li, Yan |
title |
Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
title_short |
Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
title_full |
Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
title_fullStr |
Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
title_full_unstemmed |
Fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
title_sort |
fabrication of cisplatin-loaded poly(lactide-co-glycolide) composite microspheres for osteosarcoma treatment |
publishDate |
2013 |
url |
https://hdl.handle.net/10356/105525 http://hdl.handle.net/10220/17650 http://dx.doi.org/10.1007/s11095-011-0600-9 |
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1681046488022515712 |