Peptide inhibitors of viral assembly : a novel route to broad-spectrum antivirals

• Main Authors: ElSawy, Karim M., Twarock, Reidun., Verma, Chandra S., Caves, Leo S. D.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105681; http://hdl.handle.net/10220/17754; http://dx.doi.org/10.1021/ci200467s
• Institution: Nanyang Technological University

We investigated the potential of small peptide segments to function as broad-spectrum antiviral drug leads. We extracted the α-helical peptide segments that share common secondary-structure environments in the capsid protein–protein interfaces of three unrelated virus classes (PRD1-like, HK97-like,...