Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

• Main Authors: Rajan, Sreekanth, Choi, Minjoo, Nguyen, Quoc Toan, Ye, Hong, Liu, Wei, Toh, Hui Ting, Kang, CongBao, Kamariah, Neelagandan, Li, Chi, Huang, Huiya, White, Carl, Baek, Kwanghee, Grüber, Gerhard, Yoon, Ho Sup
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/105691; http://hdl.handle.net/10220/26043

Bcl-2 family proteins are key regulators for cellular homeostasis in response to apoptotic stimuli. Bcl-xL, an antiapoptotic Bcl-2 family member, undergoes conformational transitions, which leads to two conformational states: the cytoplasmic and membrane-bound. Here we present the crystal and small-...