Molecular basis of Bcl-XL-p53 interaction : insights from molecular dynamics simulations

• المؤلفون الرئيسيون: Bharatham, Nagakumar, Chi, Seung-Wook, Yoon, Ho Sup
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/93655; http://hdl.handle.net/10220/7512
• المؤسسة: Nanyang Technological University

Bcl-XL, an antiapoptotic Bcl-2 family protein, plays a central role in the regulation of the apoptotic pathway. Heterodimerization of the antiapoptotic Bcl-2 family proteins with the proapoptotic family members such as Bad, Bak, Bim and Bid is a crucial step in the apoptotic regulation. In add...