The natively disordered loop of Bcl-2 undergoes phosphorylation-dependent conformational change and interacts with Pin1

• Main Authors: Bharatham, Nagakumar, Chia, Joel, Mu, Yuguang, Baek, Kwanghee, Yoon, Ho Sup, Kang, CongBao
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/79977; http://hdl.handle.net/10220/10901
• Institution: Nanyang Technological University

Bcl-2 plays a central role in the regulation of apoptosis. Structural studies of Bcl-2 revealed the presence of a flexible and natively disordered loop that bridges the Bcl-2 homology motifs, BH3 and BH4. This loop is phosphorylated on multiple sites in response to a variety of external stimuli, inc...