Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress

• Main Authors: Kuznetsov, Vladimir Andreevich, Vardy, Leah Anne, Ivshina, Anna Vladimirovna, Giannakakis, Antonis, Zhang, Jingxian, Jenjaroenpun, Piroon, Nama, Srikanth, Zainolabidin, Norliyana, Aau, Mei Yee, Yarmishyn, Aliaksandr A., Vaz, Candida, Grinchuk, Oleg V., Voorhoeve, Mathijs, Sampath, Prabha, Kurochkin, Igor V., Guccione, Ernesto
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/105695; http://hdl.handle.net/10220/26058
• Institution: Nanyang Technological University

Oxidative stress (OS) is caused by an imbalance between pro- and anti-oxidant reactions leading to accumulation of reactive oxygen species within cells. We here investigate the effect of OS on the transcriptome of human fibroblasts. OS causes a rapid and transient global induction of transcription c...