Synthesis and telomeric G-quadruplex-stabilizing ability of macrocyclic hexaoxazoles bearing three side chains

• المؤلفون الرئيسيون: Ma, Yue, Iida, Keisuke, Sasaki, Shogo, Hirokawa, Takatsugu, Heddi, Brahim, Nagasawa, Kazuo, Phan, Anh Tuân
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: DRNTU::Science::Physics; G-Quadruplex; Macrocyclic Oxazole
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/105834; http://hdl.handle.net/10220/48766

G-quadruplexes (G4s), which are structures formed in guanine-rich regions of DNA, are involved in a variety of significant biological functions, and therefore “sequence-dependent” selective G4-stabilizing agents are required as tools to investigate and modulate these functions. Here, we describe the...