Aza-bridged bisphenanthrolinyl Pt(ii) complexes : efficient stabilization and topological selectivity on telomeric G-quadruplexes

• Main Authors: He, Lei, Meng, Zhenyu, Xie, Yi-qun, Chen, Xiang, Li, Tianhu, Shao, Fangwei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Pt Complex; G-quadruplex
• Online Access: https://hdl.handle.net/10356/89489; http://hdl.handle.net/10220/44940
• Institution: Nanyang Technological University

Two platinum complexes with an aza-bridged bis(1,10-phenanthrolin-2-yl)amine (bpa) were synthesized. The two phenanthrolines in bpa entered a flat plane prior to binding of nucleic acids, which bestowed on the two Pt complexes a significantly high stabilizing ability on both DNA and RNA G-quadruplex...