Cabazitaxel liposomes with aptamer modification enhance tumor‑targeting efficacy in nude mice

• Main Authors: Cheng, Yuzhu, Ou, Zhanlun, Li, Qingguo, Yang, Juan, Hu, Min, Zhou, Yubin, Zhuang, Xiaodong, Guan, Shixia, Zhang, Jason Zhenyu
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Cabazitaxel; Aptamers; DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/105958; http://hdl.handle.net/10220/48829
• Institution: Nanyang Technological University

The present study investigated the feasibility of improving the tumor‑targeting efficacy and decreasing the toxicity of liposomal cabazitaxel (Cab) with aptamer modification. The process involved preparing aptamer (TLS1c)‑modified liposomes and studying the behavior of the liposomes in vitro and in...