Positron emission tomography studies with [11C]PBR28 in the healthy rodent brain: validating SUV as an outcome measure of neuroinflammation

• Main Authors: Tóth, Miklós, Doorduin, Janine, Häggkvist, Jenny, Varrone, Andrea, Amini, Nahid, Halldin, Christer, Gulyás, Balázs
• Other Authors: Hashimoto, Kenji
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/105978; http://hdl.handle.net/10220/26096
• Institution: Nanyang Technological University

Molecular imaging of the 18 kD Translocator protein (TSPO) with positron emission tomography (PET) is of great value for studying neuroinflammation in rodents longitudinally. Quantification of the TSPO in rodents is, however, quite challenging. There is no suitable reference region and the use of pl...