ABC transporter-dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369 : a comparative PET study in mouse, rat, and guinea pig

• Main Authors: Tóth, Miklós, Häggkvist, Jenny, Varrone, Andrea, Finnema, Sjoerd J, Doorduin, Janine, Tokunaga, Masaki, Higuchi, Makoto, Gulyás, Balázs, Halldin, Christer
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Zoology
• Online Access: https://hdl.handle.net/10356/103338; http://hdl.handle.net/10220/24469
• Institution: Nanyang Technological University

Background We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4, and Bcrp, in rodents and whether there is a species difference regarding i...