ABC transporter-dependent brain uptake of the 5-HT1B receptor radioligand [11C]AZ10419369 : a comparative PET study in mouse, rat, and guinea pig
Background We have explored the possibility that the serotonin 1B receptor radioligand [11C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4, and Bcrp, in rodents and whether there is a species difference regarding i...
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Main Authors: | Tóth, Miklós, Häggkvist, Jenny, Varrone, Andrea, Finnema, Sjoerd J, Doorduin, Janine, Tokunaga, Masaki, Higuchi, Makoto, Gulyás, Balázs, Halldin, Christer |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/103338 http://hdl.handle.net/10220/24469 |
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Institution: | Nanyang Technological University |
Language: | English |
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