Enhancing antigen cross-presentation in human monocyte-derived dendritic cells by recruiting the intracellular Fc receptor TRIM21

• Main Authors: Ng, Patricia M. L., Kaliaperumal, Nivashini, Lee, Chia Yin, Chin, Wen Jie, Tan, Hwee Ching, Au, Veonice B., Goh, Angeline X.-H., Tan, Qiao Wen, Yeo, Darren S. G., Connolly, John E., Wang, Cheng-I
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Antigen; Dendritic Cells; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/105989; http://hdl.handle.net/10220/48836; http://dx.doi.org/10.4049/jimmunol.1800462
• Institution: Nanyang Technological University

Suboptimal immune responses to pathogens contribute to chronic infections. One way to improve immune responses is to boost Ag presentation. In this study, we investigate the potential of the tripartite motif-containing 21 (TRIM21) pathway. TRIM21 is a ubiquitously expressed cytosolic protein that re...