Fusing gene expressions and transitive protein-protein interactions for inference of gene regulatory networks

• Main Authors: Liu, Wenting, Rajapakse, Jagath Chandana
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Engineering::Computer science and engineering; Gene Expressions; Gene Regulatory Network (GRN)
• Online Access: https://hdl.handle.net/10356/105990; http://hdl.handle.net/10220/48815; http://dx.doi.org/10.1186/s12918-019-0695-x
• Institution: Nanyang Technological University

Background: Systematic fusion of multiple data sources for Gene Regulatory Networks [GRN] inference remains a key challenge in systems biology. We incorporate information from protein-protein interaction networks [PPIN] into the process of GRN inference from gene expression [GE] data. However, exist...