Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

• المؤلفون الرئيسيون: Dutta, Pritha, Ma, Lichun, Ali, Yusuf, Sloot, Peter M.A., Zheng, Jie
• مؤلفون آخرون: School of Computer Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Boolean Model; Type 2 Diabetes Mellitus; DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/105995; http://hdl.handle.net/10220/48812

Background : Major alteration in lifestyle of human population has promoted Type 2 diabetes mellitus (T2DM) to the level of an epidemic. This metabolic disorder is characterized by insulin resistance and pancreaticβ-cell dysfunction and apoptosis, triggered by endoplasmic reticulum (ER) stress, oxid...