Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

• Main Authors: Dutta, Pritha, Ma, Lichun, Ali, Yusuf, Sloot, Peter M.A., Zheng, Jie
• 其他作者: School of Computer Science and Engineering
• 格式: Article
• 語言: English
• 出版: 2019
• 主題: Boolean Model; Type 2 Diabetes Mellitus; DRNTU::Science::Medicine
• 在線閱讀: https://hdl.handle.net/10356/105995; http://hdl.handle.net/10220/48812
• 機構: Nanyang Technological University

Background : Major alteration in lifestyle of human population has promoted Type 2 diabetes mellitus (T2DM) to the level of an epidemic. This metabolic disorder is characterized by insulin resistance and pancreaticβ-cell dysfunction and apoptosis, triggered by endoplasmic reticulum (ER) stress, oxid...