High β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in pseudomonas aeruginosa biofilms

• Main Authors: Wang, Hengzhuang, Ciofu, Oana, Yang, Liang, Wu, Hong, Song, Zhijun, Oliver, Antonio, Høiby, Niels
• 其他作者: Singapore Centre for Environmental Life Sciences Engineering
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Microbiology
• 在線閱讀: https://hdl.handle.net/10356/106011; http://hdl.handle.net/10220/26343
• 機構: Nanyang Technological University

Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role o...