Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells

• Main Authors: Yu, Haiyang, Lui, Yuan Siang, Xiong, Sijing, Leong, Wen Shing, Wen, Feng, Nurkahfianto, Himawan, Rana, Sravendra, Leong, David Tai, Ng, Kee Woei, Tan, Lay Poh
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials::Biomaterials
• Online Access: https://hdl.handle.net/10356/106290; http://hdl.handle.net/10220/23990
• Institution: Nanyang Technological University

We report the establishment of a novel platform to induce myogenic differentiation of human mesenchymal stem cells (hMSCs) via focal adhesion (FA) modulation, giving insights into the role of FA on stem cell differentiation. Micropatterning of collagen type I on a polyacrylamide gel with a stiffness...