Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

• Main Authors: Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Hyvönen, Marko, Spring, David R., Verma, Chandra Shekhar
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Peptides; Science::Biological sciences; Protein–Protein Interaction
• Online Access: https://hdl.handle.net/10356/106361; http://hdl.handle.net/10220/49635
• Institution: Nanyang Technological University

The discovery of new Protein–Protein Interaction (PPI) modulators is currently limited by the difficulties associated with the design and synthesis of selective small molecule inhibitors. Peptides are a potential solution for disrupting PPIs; however, they typically suffer from poor stability in viv...