Computational study of uracil tautomeric forms in the ribosome : the case of uracil and 5-oxyacetic acid uracil in the first anticodon position of tRNA

• Main Authors: Hartono, Yossa Dwi, Ito, Mika, Villa, Alessandra, Nilsson, Lennart
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Uracil; Science::Biological sciences; Ribosome
• Online Access: https://hdl.handle.net/10356/106400; http://hdl.handle.net/10220/49608
• Institution: Nanyang Technological University

Tautomerism is important in many biomolecular interactions, not least in RNA biology. Crystallographic studies show the possible presence of minor tautomer forms of transfer-RNA (tRNA) anticodon bases in the ribosome. The hydrogen positions are not resolved in the X-ray studies, and we have used ab...