Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane

• Main Authors: Barrett, David W., John, Rebecca K., Thrasivoulou, Christopher, Mata, Alvaro, Deprest, Jan A., Becker, David Lawrence, David, Anna L., Chowdhury, Tina T.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Biomedical Engineering; Paediatric Research; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/106493; http://hdl.handle.net/10220/48950
• Institution: Nanyang Technological University

Mechanical and inflammatory signals in the fetal membrane play an important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth. We developed a mechanical model that mimics repetitive stretching of the amniotic membrane (AM) isolated from regions over the placenta...