Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane

• المؤلفون الرئيسيون: Barrett, David W., John, Rebecca K., Thrasivoulou, Christopher, Mata, Alvaro, Deprest, Jan A., Becker, David Lawrence, David, Anna L., Chowdhury, Tina T.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Biomedical Engineering; Paediatric Research; DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106493; http://hdl.handle.net/10220/48950

Mechanical and inflammatory signals in the fetal membrane play an important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth. We developed a mechanical model that mimics repetitive stretching of the amniotic membrane (AM) isolated from regions over the placenta...