A covalent reporter of β-lactamase activity for fluorescent imaging and rapid screening of antibiotic-resistant bacteria

• Main Authors: Shao, Qing, Zheng, Yan, Dong, Xueming, Tang, Kai, Yan, Xiaomei, Xing, Bengang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/106609; http://hdl.handle.net/10220/16649; http://dx.doi.org/10.1002/chem.201301654
• Institution: Nanyang Technological University

Bacterial resistance to antibiotics poses a great clinical challenge in fighting serious infectious diseases due to complicated resistant mechanisms and time-consuming testing methods. Chemical reaction-directed covalent labeling of resistance-associated bacterial proteins in the context of a compli...