Gram-positive antimicrobial activity of amino acid-based hydrogels

Gram-positive antimicrobial activity of amino acid-based hydrogels

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-...

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Bibliographic Details
Main Authors: Irwansyah, I., Li, Yong-Qiang, Shi, Wenxiong, Qi, Dianpeng, Leow, Wan Ru, Tang, Mark B. Y., Li, Shuzhou, Chen, Xiaodong
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Engineering::Materials
Online Access:https://hdl.handle.net/10356/106702
http://hdl.handle.net/10220/25088
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Institution: Nanyang Technological University
Language: English
Description
Summary:Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.

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