Gram-positive antimicrobial activity of amino acid-based hydrogels

• Main Authors: Irwansyah, I., Li, Yong-Qiang, Shi, Wenxiong, Qi, Dianpeng, Leow, Wan Ru, Tang, Mark B. Y., Li, Shuzhou, Chen, Xiaodong
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/106702; http://hdl.handle.net/10220/25088
• Institution: Nanyang Technological University

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.