Cobalt-catalyzed enantioselective directed C-H alkylation of indole with styrenes

• المؤلفون الرئيسيون: Lee, Pin-Sheng, Yoshikai, Naohiko
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Chemistry::Organic chemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106746; http://hdl.handle.net/10220/25067
• المؤسسة: Nanyang Technological University

A cobalt–chiral phosphoramidite catalyst promotes enantioselective imine-directed C2-alkylation of Boc-protected indoles with styrenes. The reaction affords 1,1-diarylethane products in moderate to good yields with good enantioselectivities under mild conditions. A deuterium-labeling experiment sugg...