Iron-catalyzed directed C2-alkylation and alkenylation of indole with vinylarenes and alkynes

• Main Authors: Yamakawa, Takeshi, Yoshikai, Naohiko, Wong, Mun Yee
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: https://hdl.handle.net/10356/107215; http://hdl.handle.net/10220/25309
• Institution: Nanyang Technological University

An iron–N-heterocyclic carbene catalyst generated from an iron(III) salt, an imidazolinium salt, and a Grignard reagent promotes alkylation and alkenylation reactions at the indole C2-position with vinylarenes and internal alkynes, respectively, via imine-directed C–H activation. The former reaction...