Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes

• Main Authors: Yoshikai, Naohiko, Yamakawa, Takeshi
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: https://hdl.handle.net/10356/102755; http://hdl.handle.net/10220/19125
• Institution: Nanyang Technological University

A cobalt-N-heterocyclic carbene catalyst generated from CoBr2, imidazolium salt, and cyclohexylmagnesium bromide was found to promote the imine-directed C2-alkylation of indoles with nonconjugated arylalkenes through a tandem alkene isomerization–hydroarylation process, affording 1,1-diarylalkanes w...