Targeting cell membrane lipid rafts by stoichiometric functionalization of gold nanoparticles with a sphingolipid-binding domain peptide

• Main Authors: Paramelle, David, Nieves, Daniel, Brun, Benjamin, Kraut, Rachel Susan, Fernig, David G.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
• Online Access: https://hdl.handle.net/10356/106876; http://hdl.handle.net/10220/25147; http://dx.doi.org/10.1002/adhm.201400730
• Institution: Nanyang Technological University

A non-membrane protein-based nanoparticle agent for the tracking of lipid rafts on live cells is produced by stoichiometric functionalization of gold nanoparticles with a previously characterized sphingolipid- and cell membrane microdomain-binding domain peptide (SBD). The SBD peptide is inserted in...